Influence of simultaneous comorbidities on COVID-associated acute respiratory distress syndrome mortality in people with diabetes.

Objectives: This study analyzed the influence of 23 comorbidities on COVID-associated acute distress respiratory syndrome (CARDS) mortality in people with a history of diabetes mellitus. Methods: An observational, analytical, cross sectional study was utilized to investigate data from 6723 health services in Brazil, comprising 5433 people with diabetes. Adjusted logistic regression models for demographic factors such as age, sex, and race were used to analyze the association between CARDS mortality and comorbidities. Results: Persons with two (p < 0.001), three (p < 0.001), four (p < 0.001), and five (p < 0.001) simultaneous comorbidities had a higher chance of dying. We identified that diabetes patients who had concomitant metabolic diseases (p = 0.019), neurological disorders (p < 0.001), or were smokers (p < 0.001) had a higher predicted mortality risk based on CADRS. Conclusion: The number of comorbidities plays a determining role in CARDS mortality in people with diabetes, especially those who suffer from smoking and neurological diseases simultaneously.

Health-related quality of life after pediatric cochlear implantation.

OBJECTIVES: To examine the results of health-related quality of life (HRQoL) questionnaire scores from deaf children fitted with at least one cochlear implant (CI) and compare responses to normal-hearing age-peers (NHP) and to their parents. METHODS: This cross-sectional study included 33 pediatric patients with a hearing experience of at least 1 year with CI and a control group of 21 NHP. The KINDLR questionnaire for measuring HRQoL (generic) in children (7-12years) and adolescents (13-17years) and a CI questionnaire (specific) were completed by CI users and their parents. Scores were transformed to a 100-point scale with 100 representing the most positive response. RESULTS: The group of children and adolescents with CI reached a similar score in the generic HRQoL (Children:78,6; Adolescents:80,4; p = 0,35) and in the overall CI questionnaire (Children:77,6; Adolescents:75,6; p = 0,53). CI users in both age groups scored generic HRQoL similarly to their NHP (NH children:82,2, p = 0,18; NH adolescents:77,5; p = 0,07) and higher than CI users from other centers (OC) (OC children:75,4; OC adolescents:70,3). CI users scored their school domain lower than their NHP (p = 0,04). Generic and CI questionnaire scores of parents and their children correlated positively (r = 0,66, p = 0,00 and r = 0,73, p = 0,00). The total scores of HRQoL in the self-rating and parent rating correlate with none of the variables at study (gender, cause of deafness, age at implantation, years with a CI, chronological age) except with speech progression (p = 0,007). CONCLUSIONS: Children with CI experience similar quality of life as NHP. Parents are reliable reporters on the status of their child's overall quality of life.

Association between the insertion type of the uncinate process and the development of Frontal Sinus Mucoceles - is there a relationship?

BACKGROUND: The frontal sinus drainage pathway is formed by either the ethmoid infundibulum or the middle meatus, which depends on the superior insertion of the uncinate process. According to Landsberg & Friedman the are 6 types of superior uncinate process insertion. The aim of this study is to find an association between the uncinate process insertion type and the development of frontal sinus mucoceles. METHODS: Fifty sinus CT scans were analysed. Exclusion criteria were previous nasal surgeries, malignancy, polyposis and an insufficient image quality. Superior insertions of the uncinate process were analysed according to the Landsberg & Friedman classification. The results were tabulated and analysed using SPSS 25.0. RESULTS: The analysis revealed type 1 insertion in 6% of the CT scans, type 2 in 32%, type 3 in 26%, type 4 in 0%, type 5 in 28% and type 6 in 8%. Despite 44% of the CT scans with frontal sinus mucocele showing a type 2 insertion of the uncinate process, both the Chi-Square test and the Cramer's V test showed no statistical significance (p>.05). Logistic regression also showed that uncinate process insertion type does not influence the likelihood of development of frontal sinuses mucoceles. CONCLUSIONS: The insertion of the uncinate process does not influence the development of frontal sinus mucoceles.

Association between the insertion type of the uncinate process and the development of Frontal Sinus Mucoceles - is there a relationship?

Background: The frontal sinus drainage pathway is formed by either the ethmoid infundibulum or the middle meatus, which depends on the superior insertion of the uncinate process. According to Landsberg & Friedman the are 6 types of superior uncinate process insertion.The aim of this study is to find an association between the uncinate process insertion type and the development of frontal sinus mucoceles.MethodsFifty sinus CT scans were analysed. Exclusion criteria were previous nasal surgeries, malignancy, polyposis and an insufficient image quality. Superior insertions of the uncinate process were analysed according to the Landsberg & Friedman classification. The results were tabulated and analysed using SPSS 25.0.ResultsThe analysis revealed type 1 insertion in 6% of the CT scans, type 2 in 32%, type 3 in 26%, type 4 in 0%, type 5 in 28% and type 6 in 8%. Despite 44% of the CT scans with frontal sinus mucocele showing a type 2 insertion of the uncinate process, both the Chi-Square test and the Cramer's V test showed no statistical significance (p>.05). Logistic regression also showed that uncinate process insertion type does not influence the likelihood of development of frontal sinuses mucoceles.ConclusionsThe insertion of the uncinate process does not influence the development of frontal sinus mucoceles. (AU)

Antecedentes: La vía de drenaje del seno frontal es formada por el infundíbulo etmoidal o por el meato medio, lo que depende de la inserción superior de la apófisis unciforme. Según Landsberg y Friedman hay seis tipos de inserción superior de la apófisis unciforme.El objetivo del estudio es entender si hay alguna correlación entre el tipo de inserción de la apófisis unciforme y el desarrollo de mucoceles del seno frontal.Material y métodosSe analizaron 50 tomografías computarizadas de los senos paranasales. Los criterios de exclusión fueron cirugías nasales previas, malignidad, poliposis y una calidad de imagen insuficiente. Las inserciones superiores de la apófisis unciforme fueron analizadas según la clasificación de Landsberg y Friedman. Los resultados se tabularon y analizaron usando el SPSS 25.0.ResultadosEl análisis reveló la inserción de tipo 1 en 6% de las tomografías computarizadas, tipo 2 en 32%, tipo 3 en 26%, tipo 4 en 0%, tipo 5 en 28% y tipo 6 en 8%. A pesar de que el 44% de las tomografías computarizadas con mucocele del seno frontal muestran una inserción de tipo 2 de la apófisis unciforme, tanto la prueba de X2 como la prueba de V de Cramer, no mostraron significación estadística (p > 0,05). La regresión logística también demostró que el tipo de inserción de la apófisis unciforme no influye en la probabilidad de desarrollo de mucoceles de los senos frontales.ConclusiónLa inserción de la apófisis unciforme no influye el desarrollo de los mucoceles en los senos frontales. (AU)

Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV-Negative Patient with Thymoma.

INTRODUCTION: Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients' immune responses. METHODS: Case report using clinical records. RESULTS: Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis. The patient was referred to an otolaryngology consultation with complaints of facial pain in the right malar region, interpreted as an acute sinusitis. Following examination, an expansive maxillary sinus mass was found, and endoscopic surgery was undertaken. After careful investigation, it was diagnosed as a Kaposi sarcoma. CONCLUSIONS: It is thought to be the first described case of a maxillary sinus Kaposi sarcoma in an HIV-negative patient. Thus, this entity has to be considered in the differential diagnosis of sinus masses, even in non-HIV patients.

Recovery of cochlear and vestibular function after labyrinthine haemorrhage.

Inner ear haemorrhage is a rare disorder with disabling symptoms. Prognosis is generally considered to be poor with essentially no chance of functional recovery. The most common aetiologies are related to blood dyscrasias, anticoagulant therapy or local trauma. The association with autoimmune diseases is exceptional. The authors report a case of sudden deafness with vertigo in a patient with rheumatoid arthritis, caused by labyrinthine haemorrhage. Clinical picture and progress of audiovestibular function are described along with imagiological features from magnetic resonance imaging. Inner ear haemorrhage is a rare disorder with disabling symptoms and poor prognosis. To the best of the authors' knowledge, this is the first case described with documented vestibular function recovery following labyrinthine haemorrhage.

A hemorragia do ouvido interno é uma doença rara com sintomas incapacitantes e mau prognóstico funcional. As etiologias mais comuns estão relacionadas com discrasias sanguíneas, terapêutica anticoagulante ou traumatismo local. A associação com doenças autoimunes é excecional. Os autores relatam um caso de surdez súbita e vertigem em doente com artrite reumatóide, causada por hemorragia labiríntica. O quadro clínico e a evolução da função audiovestibular são descritos juntamente com os achados imagiológicos em ressonância magnética. Tanto quanto é do conhecimento dos autores, este é o primeiro caso descrito de recuperação da função vestibular após hemorragia labiríntica.

[Impact of early elective tracheotomy in critically ill patients]. / Impacto da traqueotomia eletiva precoce nos doentes críticos.

INTRODUCTION: Tracheotomy is one of the most frequent surgical procedures performed in critically ill patients hospitalized at intensive care units. The ideal timing for a tracheotomy is still controversial, despite decades of experience. OBJECTIVE: To determine the impact of performing early tracheotomies in critically ill patients on duration of mechanical ventilation, intensive care unit stay, overall hospital stay, morbidity, and mortality. METHODS: Retrospective and observational study of cases subjected to elective tracheotomy at one of the intensive care units of this hospital during five consecutive years. The patients were stratified into two groups: early tracheotomy group (tracheotomy performed from day one up to and including day seven of mechanical ventilation) and late tracheotomy group (tracheotomy performed after day seven). The outcomes of the groups were compared. RESULTS: In the early tracheotomy group, there was a statistically significant reduction in duration of mechanical ventilation (6 days vs. 19 days; p<0.001), duration of intensive care unit stay (10 days vs. 28 days; p=0.001), and incidence of ventilator-associated pneumonia (1 case vs. 44 cases; p=0.001). CONCLUSION: Early tracheotomy has a significant positive impact on critically ill patients hospitalized at this intensive care unit. These results support the tendency to balance the risk-benefit analysis in favor of early tracheotomy.

Impact of early elective tracheotomy in critically ill patients / Impacto da traqueotomia eletiva precoce nos doentes críticos

INTRODUCTION: Tracheotomy is one of the most frequent surgical procedures performed in critically ill patients hospitalized at intensive care units. The ideal timing for a tracheotomy is still controversial, despite decades of experience. OBJECTIVE: To determine the impact of performing early tracheotomies in critically ill patients on duration of mechanical ventilation, intensive care unit stay, overall hospital stay, morbidity, and mortality. METHODS: Retrospective and observational study of cases subjected to elective tracheotomy at one of the intensive care units of this hospital during five consecutive years. The patients were stratified into two groups: early tracheotomy group (tracheotomy performed from day one up to and including day seven of mechanical ventilation) and late tracheotomy group (tracheotomy performed after day seven). The outcomes of the groups were compared. RESULTS: In the early tracheotomy group, there was a statistically significant reduction in duration of mechanical ventilation (6 days vs. 19 days; p < 0.001), duration of intensive care unit stay (10 days vs. 28 days; p = 0.001), and incidence of ventilator-associated pneumonia (1 case vs. 44 cases; p = 0.001). CONCLUSION: Early tracheotomy has a significant positive impact on critically ill patients hospitalized at this intensive care unit. These results support the tendency to balance the risk-benefit analysis in favor of early tracheotomy. .

INTRODUÇÃO: A traqueotomia é um dos procedimentos cirúrgicos mais frequentes em doentes críticos internados em unidades de terapia intensiva. O seu timing ideal é ainda, apesar de décadas de experiência, uma questão controversa. OBJETIVOS: Determinar o impacto da realização de traqueotomias precoces em doentes críticos na duração da ventilação mecânica, do internamento na unidade de terapia intensiva, do internamento hospitalar, e mortalidade e morbidade. MÉTODO: Estudo observacional retrospectivo dos casos submetidos à traqueotomia eletiva em uma das unidades de terapia intensiva do nosso hospital durante 5 anos consecutivos. Os doentes foram divididos em dois grupos, tendo sido submetidos a traqueotomias precoces (até o 7º dia de ventilação mecânica, inclusive) ou tardias (após o 7º dia de ventilação mecânica), e os resultados foram comparados. RESULTADOS: Nos doentes submetidos a uma traqueotomia precoce verificou-se uma redução estatisticamente significativa na duração da ventilação mecânica (6 dias vs. 19 dias; p < 0,001), na duração do internamento na unidade de terapia intensiva (10 dias vs. 28 dias; p = 0,001) e na incidência de pneumonia associada ao ventilador (1 caso vs. 44 casos; p = 0,001). CONCLUSÃO: A traqueotomia precoce tem um impacto positivo estatisticamente significativo nos doentes críticos. Os resultados suportam a tendência de equilibrar o risco-benefício em favor da traqueotomia precoce. .